Bis(4-nitrophenyl) carbonate → HCID 58482076, compound

Participants

Reaction Steps

A solution of (4-ethynylphenyl)(9H-fluoren-9-yl)methanol (1.0 equivalent) in THF is added to a 1.0 M solution of LiHMDS (1.0 equivalent) in THF at −78° C. After 15 minutes, a solution of bis(4-nitrophenyl) carbonate (1.5 equivalent) is added. The mixture is allowed to warm slowly to ambient temperature, quenched by addition of 1 N HCl, and extracted with ether. The extract is washed sequentially with 1 N HCl, water, and brine, then dried over mgSO4, filtered, and evaporated. The product 4-nitrophenyl carbonate is purified by chromatography on silica gel.

Provenance & Evidence