反应详情

521 mg (1.06 mmol)N-oleyl-palmitylamine in 10 ml anhydrous dichloromethane are dissolved in a 50 ml round-bottom flask and 289 mg (1.17 mmol) EEDQ are added. Subsequently, 500 mg (1.17 mmol) Boc-Dap(Fmoc)-OH are added under steering and the mixture is steered at room temperature for 20 hours. The solution is transferred with 80 ml dichloromethane into a separating funnel and washed three times with 20 ml 0.1 N HCl each and once with 20 ml saturated NaHCO3 solution. After drying over Na2SO4 the solvent is removed using a rotary evaporator (FIG. 4). A yellowish viscous oil is obtained which is not further purified. In thin layer chromatography using hexane/ethylacetate of 1:1 a Rf of 0.70 was observed.

1. washwashed three times with 20 ml 0.1 N HCl each and once with 20 ml saturated NaHCO3 solution
2. dry with materialAfter drying over Na2SO4 the solvent
3. customis removed
4. customa rotary evaporator (FIG. 4)
5. customA yellowish viscous oil is obtained which