HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ferulic Acid → Sitagliptin Ferulate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ferulic Acid | HCID 445858 | — |
| Reactant | Sitagliptin | HCID 4369359 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Sitagliptin Ferulate | HCID 178490572 | — |
Reaction Steps
Sitagliptin free base (2.0 gms) and ferulic acid (0.95 gms) were dissolved in acetonitrile (16 ml) at 60° C. to 65° C. and the reaction mass left for slow solvent evaporation at room temperature for 48 hours. Precipitated solids were filtered off and dried at 50° C. to 55° C. for 6 hours to obtain the title compound. Yield: 1.45 gms.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388113B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-7c676685eb124493a7f72411534ef20a |
| Source note | uspto-grants-2016_07 |