HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl Ether → Sitagliptin Ferulate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | Ferulic Acid | HCID 445858 | — |
| Reactant | Sitagliptin | HCID 4369359 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Sitagliptin Ferulate | HCID 178490572 | — |
Reaction Steps
Sitagliptin free base (2.0 gms) and ferulic acid (0.95 gms) were dissolved in methanol (12 ml) at 60° C. to 65° C. and the resultant solution was cooled to room temperature. Isopropyl ether (120 ml) was added to the clear solution and stirred for 12 hours. Filtered the precipitated solids and dried at 70° C. to 75° C. for 12 hours to obtain the title compound. Yield: 1.21 gms.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388113B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-3529903c0bb24b918f577d053e5ebb53 |
| Source note | uspto-grants-2016_07 |