Hydrochloric Acid → (E)-2-(2-(Quinolin-2-yl)prop-1-enyl)phenol Hydrochloride

HRID 1050921ノート

反応式

HRID 1050921 の反応式
[ClH:1].[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1/[C:12](/[CH3:21])=[CH:13]/[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[OH:20]>C(OCC)C>[ClH:1].[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1/[C:12](/[CH3:21])=[CH:13]/[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[OH:20]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 136259826(E)-2-(2-(Quinolin-2-yl)prop-1-enyl)phenol

生成物 1

HCID 136259825(E)-2-(2-(Quinolin-2-yl)prop-1-enyl)phenol Hydrochloride収率 80%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of hydrochloric acid (2.0 M in diethyl ether, 0.19 mL, 0.38 mmol, 1.0 eq.) was added dropwise to a stirred suspension of (E)-2-(2-(quinolin-2-yl)prop-1-enyl)phenol (100 mg, 0.38 mmol, 1.0 eq.) in dry diethyl ether (5 mL). The mixture was stirred at r.t. for 30 min and was filtered. The solids were washed with diethyl ether (2×5 mL) and were dried under reduced pressure yielding the product (90 mg, 80% yield) as a bright yellow solid; 1H NMR (400 MHz, DMSO-d6) δ 2.41 (s, 3H, CH3), 6.89 (t, J=7.5 Hz, 1H, Ar), 6.94 (d, J=7.5 Hz, 1H, Ar), 7.20 (t, J=7.5 Hz, 1H, Ar), 7.39 (d, J=7.5 Hz, 1H, Ar), 7.64 (s, 1H, C═CH), 7.72 (t, J=7.5 Hz, 1H, Ar), 7.92 (t, J=7.5 Hz, 1H, Ar), 8.13 (d, J=8.5 Hz, 2H, Ar), 8.27 (d, J=7.5 Hz, 1H, Ar), 8.71 (d, J=7.5 Hz, 1H, Ar), 9.88 (br s, 1H, OH).

後処理

  1. filtrationwas filtered
  2. washThe solids were washed with diethyl ether (2×5 mL)
  3. customwere dried under reduced pressure

出典と根拠

ORDレコード
ord-2ae7cee90d914392984d6b0846a9f90f
出典データセット
uspto-grants-2016_07
特許番号
US09388138B2

反応ノート

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