HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1050935Generated: October 26, 2026
Acetonitrile → N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)-3-nitrobenzenesulfonamide
https://huagongshe.com/reaction/1050935
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 2-Chloro-5-methoxyanilinium chloride | HCID 2723900 | — |
| Reactant | N-(3-chloroquinoxalin-2-yl)-3-nitrobenzenesulfonamide | HCID 5007601 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)-3-nitrobenzenesulfonamide | HCID 57448456 | — |
Reaction Steps
Prepare a solution with 0.585 kg of 2-chloro-5-methoxyaniline-HCl, 3.5 volumes of acetonitrile and 0.46 kg of DBU. (solution A) Mix 1 kg of N-(3-chloroquinoxalin-2-yl)-3-nitrobenzenesulfonamide and 5.5 volumes of acetonitrile. Heat to reflux. Add solution A and 1 volume of acetonitrile onto the reaction mixture. After completion of the reaction at reflux, cool down at 20° C., dilute with 10 volumes of methanol and filter. Wash the cake 3 times with 5 volumes of methanol and dry it under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09388143B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-72ae39d2c6da44d48c250df8ea1cc4da |
|---|
| Source note | uspto-grants-2016_07 |
|---|
