HCID 89533690, compound → HCID 89533688, compound

Participants

Reaction Steps

A solution of 25.0 g (0.08 mol, 1.0 eq) of methyl (S)-1-(2-fluoro-3-nitrobenzoyl)pyrrolidine-2-carboxylate in 250 ml of methanol in the presence of 7.0 g (28% by weight) of palladium on carbon at 10% was stirred under a hydrogen atmosphere at ambient temperature for 4 days. The reaction medium was filtered through celite and washed with 100 ml of methanol. The filtrate was evaporated. 22.80 g of methyl (S)-1-(3-amino-2-fluorobenzoyl)pyrrolidine-2-carboxylate were obtained in the form of a light oil. Quantitative yield.

Provenance & Evidence