HCID 89533691, compound → HCID 89533692, compound

Participants

Reaction Steps

A solution of 2.12 g (6.55 mmol, 1.0 eq) of isopropyl (S)-1-(2-fluoro-3-nitrobenzoyl)pyrrolidine-2-carboxylate in 40 ml of methanol in the presence of 0.32 g (15% by weight) of palladium on carbon at 10% was stirred under a hydrogen atmosphere at ambient temperature for 16 hours. The reaction medium was filtered through celite and concentrated to dryness. 1.87 g of isopropyl (S)-1-(3-amino-2-fluorobenzoyl)pyrrolidine-2-carboxylate were obtained in the form of a colorless oil. Yield=97%.

Provenance & Evidence