反应详情

11 ml (205 mmol; 1.20 V) of sulfuric acid and 11 ml of water were added dropwise to a solution of 9.12 g (28.8 mmol; 1.0 eq) of 2-tert-butyl-6-chlorobenzooxazole-7-sulfonic acid dimethylamide in 41 ml of 1,4-dioxane. The reaction medium was refluxed for six and a half hours. The reaction medium was concentrated and 440 ml of 1 N sodium hydroxide were added (pH at 8). The solution was extracted with ethyl acetate. The organic phases were combined, dried over magnesium sulfate, filtered and evaporated. 6.94 g of 3-amino-6-chloro-2-hydroxy-N,N-dimethylbenzenesulfonamide were obtained in the form of a brown solid. Yield=96%.

1. temperatureThe reaction medium was refluxed for six and a half hours
2. concentrationThe reaction medium was concentrated
3. addition440 ml of 1 N sodium hydroxide were added (pH at 8)
4. extractionThe solution was extracted with ethyl acetate
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated