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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1051074Generated: November 2, 2026

3-Bromo-5-trifluoromethoxybenzoic acid methylester → Methyl 3-cyano-5-(trifluoromethoxy)benzoate

https://huagongshe.com/reaction/1051074

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-5-trifluoromethoxybenzoic acid methylesterHCID 53419621—
ReactantMethyl 3-cyano-5-isopropoxybenzoateHCID 67195394—
ProductMethyl 3-cyano-5-(trifluoromethoxy)benzoateHCID 67192787—

Reaction Steps

Prepared from methyl 3-bromo-5-(trifluoromethoxy)benzoate according to the procedure for methyl 3-cyano-5-isopropoxybenzoate. LCMS-ESI (m/z) calculated for C10H6F3NO3: 245.2; no m/z observed, tR=4.43 min. 1H NMR (400 MHz, CDCl3) δ 8.27 (t, J=1.4 Hz, 1H), 8.16-8.07 (m, 1H), 7.73-7.65 (m, 1H), 3.99 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09388147B2
Source datasetuspto-grants-2016_07
ORD IDord-ab3f5ebc3b5e45e79a45635a97038814
Source noteuspto-grants-2016_07