Lithium Hydroxide → 2-(3-(N-(6-(3-Fluorophenyl)-2,3-dihydro-1H-inden-1-yl)acetamido)phenoxy)acetic acid

Participants

Reaction Steps

Aqueous lithium hydroxide (1 N, 1 mL, 1 mmol) was added to a solution of methyl 2-(3-(N-(6-(3-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)acetamido)phenoxy)acetate (7 mg, 0.016 mmol) in THF (1 mL) in a scintillation vial. The vial was sealed and stirred overnight at room temperature. After 24 h, the reaction mixture was allowed to cool and the volatiles were concentrated. The residue was acidified with hydrochloric acid (1 N, 1 mL) and extracted with ethyl acetate (3×2 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated to afford 4 mg (59%) of the title compound.

Provenance & Evidence