Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 10511생성일: 2026년 10월 25일
N-(tert-Butoxycarbonyl)-1,5-diaminopentane → N-(tert-butoxycarbonyl)-N'-(5-isoquinolyl)-pentamethylenediamine
https://huagongshe.com/reaction/10511
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-(tert-Butoxycarbonyl)-1,5-diaminopentane | HCID 4352 | — |
| 반응물 | 5-Bromoisoquinoline | HCID 736487 | — |
| 반응물 | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-(tert-butoxycarbonyl)-N'-(5-isoquinolyl)-pentamethylenediamine | HCID 21979906 | 84.3% |
반응 단계
Under nitrogen atmosphere, a suspension of 5-bromoisoquinoline (245 mg), tris(dibenzylideneacetone)palladium(0) (56 mg), 2-(di-tert-butylphosphino)biphenyl (69 mg), N-(5-aminopentyl)carbamic acid tert-butyl ester (282 mg, Tokyo Kasei Kogyo) and sodium tert-butoxide (160 mg) in toluene was stirred with heating at 70° C. for 4.5 hours. The reaction mixture was cooled to room temperature and purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (327 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07094789B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-600f4b91275841b0837efb247cf9997c |
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| 출처 메모 | uspto-grants-2006_08 |
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