Lithium Hydroxide → 2-(3-((6-(3-Fluorophenyl)-2,3-dihydro-1H-inden-1-yl)oxy)phenoxy)acetic acid

Participants

Reaction Conditions

Reaction Steps

Aqueous lithium hydroxide (1 N, 1 mL, 1 mmol) was added to a solution of methyl 2-(3-((6-(3-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)oxy)phenoxy)acetate (38 mg, 0.091 mmol) in THF (1 mL) in a scintillation vial. The vial was sealed and stirred overnight at 40° C. After 24 h, the reaction mixture was allowed to cool and the volatiles were concentrated. The residue was acidified with hydrochloric acid (1 N, 1 mL) and extracted with ethyl acetate (3×2 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated. The resulting crude residue was purified by preparative TLC (1000 mm thickness, 15% methanol/dichloromethane) to afford 21 mg (61%) of the title compound.

Provenance & Evidence