Lithium Hydroxide → 2-(3-((5-(3-Fluorophenyl)-2,3-dihydrobenzofuran-3-yl)amino)phenoxy)acetic acid

Participants

Reaction Conditions

Reaction Steps

Aqueous lithium hydroxide (1 N, 1 mL, 1 mmol) was added to a solution of isopropyl 2-(3-((5-(3-fluorophenyl)-2,3-dihydrobenzofuran-3-yl)amino)phenoxy)acetate (22 mg, 0.052 mmol) in THF (1 mL) in a scintillation vial. The vial was sealed and heated at 40° C. After 24 h, the reaction mixture was allowed to cool and the volatiles were concentrated. The residue was acidified with hydrochloric acid (1 N, 1 mL), and extracted with ethyl acetate (3×2 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated to afford 11 mg (56%) of the title compound.

Provenance & Evidence