HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-7-fluoro-6-nitroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178526403 | HCID 178526403 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-7-fluoro-6-nitroquinazoline | HCID 10609358 | 94.4% |
Reaction Steps
7-fluoro-6-nitroquinazolin-4-ol (15 g, 0.072 mol) was added to 150 ml SOCl2 and 10 drops of DMF was added. The solution was heated to reflux for 4 hours which become a clear solution, then the SOCl2 was removed under reduce pressure to give 4-chloro-7-fluoro-6-nitroquinazoline as yellow powder 15.4 g (94.4% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388160B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-bf17cc17249648a7a2825e5ddf7d6505 |
| Source note | uspto-grants-2016_07 |