反应详情

温度

80 °C

Na (1.4 g, 0.060 mol) was carefully dissolved in 80 ml of anhydrous ethanol to form a clear solution, then N-(3-ethynylphenyl)-7-fluoro-6-nitroquinazolin-4-amine (8 g, 0.025 mol) was added and stirred for 4 hours at 80° C. The solution was concentrated under reduced pressure to remove excess ethanol, and 50 ml H2O was added. The resulting solid precipitate was filtered and dried under vacuum to get 7-ethoxy-N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine as yellow solid 8.1 g (93.4% yield).

1. customto form a clear solution
2. concentrationThe solution was concentrated under reduced pressure
3. customto remove excess ethanol, and 50 ml H2O
4. additionwas added
5. filtrationThe resulting solid precipitate was filtered
6. customdried under vacuum