5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile → 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile

HRID 1051122Notes

Reaction equation

HRID 1051122 reaction equation
[C:1]([C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][C:6]([N+:13]([O-])=O)=[CH:5][N:4]=1)#[N:2].[H][H]>[Ni]>[C:1]([C:3]1[C:8]([C:9]([F:12])([F:10])[F:11])=[CH:7][C:6]([NH2:13])=[CH:5][N:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 218748935-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrileHCID 178418361HCID 178418361, compound

Product 1

HCID 135322465-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Alternatively, 2-cyano-3-(trifluoromethyl)-5-nitropyridine A10 can be reacted with hydrogen over Raney-Ni to obtain 2-cyano-3-(trifluoromethyl)-5-aminopyridine, A11.

Sources & evidence

ORD record
ord-a6e0b2faec4d4376bbd5b8d381ee569a
Source dataset
uspto-grants-2016_07
Patent number
US09388159B2

Reaction notes

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