反应详情

To a stirred solution of 4-(4-nitro-1H-benzimidazol-1-yl)benzonitrile (1.2 g, 4.54 mmol) in ethanol (100 mL) at rt was added Pd/C 10% (96 mg) in one portion and the mixture was stirred under a hydrogen atmosphere at normal pressure for 26 h. The suspension was filtered, and the solution was evaporated. Purification of the residue by flash chromatography yielded 4-(4-amino-1H-benzimidazol-1-yl)benzonitrile (0.45 g, 42.3%).

1. filtrationThe suspension was filtered
2. customthe solution was evaporated
3. customPurification of the residue by flash chromatography