反应详情

温度

90 °C

To a stirred solution of 4-{4-[(2-methylpropyl)amino]-1H-benzimidazol-1-yl}benzonitrile (220 mg, 0.758 mmol) in ethanol (14 m L) at rt was added sodium hydroxide (7 N aqueous solution, 14 mL) in one portion. After stirring at 90° C. for 24 h, the mixture is cooled to rt and acidified with citric acid (10% aqueous solution). The precipitate was filtered, and the remaining solid was washed and dried to yield 4-{4-[(2-methylpropyl)amino]-1H-benzimidazol-1-yl}benzoic acid as a white solid (215 mg, 91.7%).

1. temperaturethe mixture is cooled to rt
2. filtrationThe precipitate was filtered
3. washthe remaining solid was washed
4. customdried