HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1051183Generated: November 2, 2026
Diisopropylethylamine → HCID 66562066, compound
https://huagongshe.com/reaction/1051183
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68386877 | HCID 68386877 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66562066 | HCID 66562066 | 85% |
Reaction Steps
To a solution of 44 mg (114 μmol) 4-[4-(isobutylamino)-6-phenyl-1H-benzimidazol-1-yl]benzoic acid which was prepared according to intermediate example 4-2 in 2.8 mL THF were added 47.7 mg HATU, 22 μL N,N-diisopropylethylamine and the mixture was stirred at 23° C. for 20 hours. The solvent was removed and the residue purified by chromatography to give 41.0 mg (85%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09388140B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-8afd1fc7c301408588e0af2cde8044d0 |
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| Source note | uspto-grants-2016_07 |
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