Hydrochloric Acid → HCID 68386741, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 275 mg (564 μmol) methyl 4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzoate which was prepared according to intermediate example 10b in 12 mL tetrahydrofurane and 4 mL methanol were added 2.8 mL of a 1M aqueous lithium hydroxide solution and the mixture was stirred at 23° C. overnight. Water was added, the mixture was acidified by the addition of a 1M hydrochloric acid and extracted with dichloromethane and methanol. The organic layer was washed with brine and dried over sodium sulfate. After filtration and removal of solvent the residue was purified by chromatography to give 246 mg (88%) of the title compound.

Provenance & Evidence