Hydrochloric Acid → HCID 68386976, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 660 mg (1.25 mmol) methyl 4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzoate which was prepared according to intermediate example 101b in 25 mL tetrahydrofurane and 8 mL methanol were added 6.2 mL of a 1M aqueous lithium hydroxide solution and the mixture was stirred at 23° C. overnight. Water was added, the mixture was acidified by the addition of a 1M hydrochloric acid and extracted with dichloromethane and methanol. The organic layer was washed with brine and dried over sodium sulfate. After filtration and removal of solvent the residue was purified by chromatography to give 632 mg (98%) of the title compound.

Provenance & Evidence