反应详情

A mixture of 4,6-dichloro-5-fluoropyrimidine (5.0 g, 30.0 mmol, 1.0 equiv) and tributyl(vinyl)tin (10.4 g, 33.0 mmol, 1.1 equiv) in dichloromethane (50 mL) was degassed with a stream of with nitrogen for 10 minutes. Bis(triphenylphosphine) palladium(II) chloride (0.53 g, 0.75 mmol, 0.025 equiv) was added. The resulting mixture was degassed with a stream of nitrogen for an additional 15 minutes and heated at reflux for 72 hours. The reaction mixture was cooled to room temperature and quenched with an aqueous potassium fluoride solution (2 M, 75 mL, 5 equiv). The resulting mixture was allowed to stir for 2 hours and filtered through Celite®. The filtrate was poured into a separatory funnel and separated. The organic layer was washed with water (20 mL) and saturated brine (20 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure at 20° C. The resulting crude product was purified on an AnaLogix® (SF40-115 g) column. The gradient utilized for the purification was 10 minutes isocratic pentane, followed by a 20 minutes ramp to 5% diethyl ether in pentane. The pure fractions were combined and concentrated under reduced pressure at 20° C. to give 4-chloro-5-fluoro-6-vinylpyrimidine (3.0 g, 63% yield).

1. customwas degassed with a stream of with nitrogen for 10 minutes
2. customThe resulting mixture was degassed with a stream of nitrogen for an additional 15 minutes
3. temperatureheated
4. temperatureat reflux for 72 hours
5. filtrationfiltered through Celite®
6. additionThe filtrate was poured into a separatory funnel
7. customseparated
8. washThe organic layer was washed with water (20 mL) and saturated brine (20 mL)
9. dry with materialdried over sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated under reduced pressure at 20° C
12. customThe resulting crude product was purified on an AnaLogix® (SF40-115 g) column
13. customThe gradient utilized for the purification
14. waitwas 10 minutes
15. waitisocratic pentane, followed by a 20 minutes ramp to 5% diethyl ether in pentane
16. concentrationconcentrated under reduced pressure at 20° C.