Trifluoroacetic acid → HCID 90103105, compound

Participants

Reaction Steps

A solution of [2-(4-iodo-2-methoxy-pyridin-3-yl)-1H-indol-6-yl]-carbamic acid tert-butyl ester (90 mg, 0.19 mmol) in CH2Cl2 (5 mL) was added 2,2,2-trifluoroacetic acid (0.5 mL) at 25° C. The solution was heated to reflux for 3 h. Concentrate the solution in vacuo to afford crude 2-(4-iodo-2-methoxy-pyridin-3-yl)-1H-indol-6-ylamine (65 mg, 92%) as light yellow oil. The crude product was used directly for next step. MH+ 365.9.

Provenance & Evidence