HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(4-chloro-2-methoxy-pyridin-3-yl)-1H-indol-6-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [2-(4-chloro-2-methoxy-pyridin-3-yl)-1H-indol-6-yl]-carbamic acid tert-butyl ester | HCID 90102920 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-chloro-2-methoxy-pyridin-3-yl)-1H-indol-6-ylamine | HCID 90102891 | 90% |
Reaction Steps
A solution of [2-(4-chloro-2-methoxy-pyridin-3-yl)-1H-indol-6-yl]-carbamic acid tert-butyl ester (160 mg, 0.43) in CH2Cl2 (5 mL) was added 2,2,2-trifluoroacetic acid (0.5 mL) at 25° C. The solution was heated to reflux for 3 hours. Concentrate the solution in vacuo to afford crude 2-(4-chloro-2-methoxy-pyridin-3-yl)-1H-indol-6-ylamine (105 mg, 90%) as light yellow oil. The crude product was used directly for next step. MH+ 273.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388166B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-9cfc0a3644124d9b8558e7eafcae5212 |
| Source note | uspto-grants-2016_07 |