Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1051253Generated: October 26, 2026

3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide → 1-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

https://huagongshe.com/reaction/1051253

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamideHCID 20119694—
Reactant1-(t-Butylamino)isoquinoline-5-carboxylic acidHCID 82571105—
Product1-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamideHCID 118090796100%

Reaction Steps

The procedures of Step (3) of Example 1 were repeated, except for using 1-(t-butylamino)isoquinoline-5-carboxylic acid (0.33 g, 1.35 mmol) obtained in Step (6) of Preparation Example 1 and 3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide obtained in Step (2) above to obtain the title compound (88 mg, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09388165B2
Source datasetuspto-grants-2016_07
ORD IDord-c00b8679e6474e56b4db2c46e96c81d2
Source noteuspto-grants-2016_07