HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide → 1-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | HCID 20119694 | — |
| Reactant | 1-(t-Butylamino)isoquinoline-5-carboxylic acid | HCID 82571105 | — |
| Product | 1-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide | HCID 118090796 | 100% |
Reaction Steps
The procedures of Step (3) of Example 1 were repeated, except for using 1-(t-butylamino)isoquinoline-5-carboxylic acid (0.33 g, 1.35 mmol) obtained in Step (6) of Preparation Example 1 and 3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide obtained in Step (2) above to obtain the title compound (88 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388165B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-c00b8679e6474e56b4db2c46e96c81d2 |
| Source note | uspto-grants-2016_07 |