4-Chloro-3-(trifluoromethyl)aniline → 1-amino-N-(5-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)isoquinoline-5-carboxamide

HRID 1051254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051254
C([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)(C)(C)C.[Cl:39]C1C=CC(N)=CC=1C(F)(F)F>>[NH2:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:32]=[CH:31][C:30]([Cl:39])=[C:29]([C:33]([F:34])([F:35])[F:36])[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1

Komponenten

3

Edukt 2

HCID 675744-Chloro-3-(trifluoromethyl)anilineHCID 1180907961-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

Produkt 1

HCID 1180908211-amino-N-(5-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)isoquinoline-5-carboxamideAusbeute 24 %

Versuchsvorschrift

The procedures of Steps (1), (2) and (3) of Example 2 and Step (4) of Example 1 were repeated step by step, except for using 4-chloro-3-(trifluoromethyl)aniline instead of aniline in Step (1) of Example 2 to obtain the title compound (30 mg, 24%).

Quellen und Nachweise

ORD-Eintrag
ord-85a93f36b36e44fc93bf7700375039a9
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388165B2

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