Aniline → 1-amino-N-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

HRID 1051265노트

반응식

HRID 1051265 반응식
C([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])NC4C=CC=C(C(F)(F)F)C=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)(C)(C)C.[CH3:39][C:40]1[N:41]=[CH:42][N:43]([C:45]2[CH:46]=[C:47]([CH:49]=[C:50]([C:52]([F:55])([F:54])[F:53])[CH:51]=2)[NH2:48])[CH:44]=1.NC1C=CC=CC=1>>[NH2:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:48][C:47]4[CH:49]=[C:50]([C:52]([F:55])([F:53])[F:54])[CH:51]=[C:45]([N:43]5[CH:44]=[C:40]([CH3:39])[N:41]=[CH:42]5)[CH:46]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1

참가 물질

4

반응물 3

HCID 6115AnilineHCID 120028253-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)anilineHCID 1180907961-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

생성물 1

HCID 1180907911-amino-N-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide수율 7.5%

실험 절차

The procedures of Steps (1), (2) and (3) of Example 2 and Step (4) of Example 1 were repeated step by step, except for using 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline obtained in Step (1) above instead of aniline in Step (1) of Example 2 to obtain the title compound (3.0 mg, 7.5%).

출처 및 근거

ORD 기록
ord-18f985fbdbdf40bd9eda8b2f05ce97af
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388165B2

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