HRID1051265

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6115

Aniline

C6H7N

HCID12002825

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

C11H10F3N3

结构：Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12

HCID118090796

未命名化合物

PRODUCTS

生成物

结构：Cc1cn(-c2cc(NC(=O)c3ccc(C)c(NC(=O)c4cccc5c(N)nccc45)c3)cc(C(F)(F)F)c2)cn1

HCID118090791

未命名化合物

收率 7.5%

PROCEDURE

实验过程

The procedures of Steps (1), (2) and (3) of Example 2 and Step (4) of Example 1 were repeated step by step, except for using 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline obtained in Step (1) above instead of aniline in Step (1) of Example 2 to obtain the title compound (3.0 mg, 7.5%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-18f985fbdbdf40bd9eda8b2f05ce97af
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09388165B2
来源说明: uspto-grants-2016_07

反应 SMILES

C([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])NC4C=CC=C(C(F)(F)F)C=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)(C)(C)C.[CH3:39][C:40]1[N:41]=[CH:42][N:43]([C:45]2[CH:46]=[C:47]([CH:49]=[C:50]([C:52]([F:55])([F:54])[F:53])[CH:51]=2)[NH2:48])[CH:44]=1.NC1C=CC=CC=1>>[NH2:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:48][C:47]4[CH:49]=[C:50]([C:52]([F:55])([F:53])[F:54])[CH:51]=[C:45]([N:43]5[CH:44]=[C:40]([CH3:39])[N:41]=[CH:42]5)[CH:46]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1