2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → HCID 118090891, compound

HRID 1051269Notes

Reaction equation

HRID 1051269 reaction equation
[C:1]([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([NH:25][C:26]([NH:28][C:29]4[CH:34]=[CH:33][C:32](Cl)=[C:31]([C:36]([F:39])([F:38])[F:37])[CH:30]=4)=[O:27])[CH:22]=[CH:21][C:20]=3[CH3:40])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2].[F:41]C1C=CC(C(F)(F)F)=CC=1N=C=O>>[C:1]([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([NH:25][C:26]([NH:28][C:29]4[CH:30]=[C:31]([C:36]([F:39])([F:38])[F:37])[CH:32]=[CH:33][C:34]=4[F:41])=[O:27])[CH:22]=[CH:21][C:20]=3[CH3:40])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 118090878HCID 118090878, compound

Product 1

HCID 118090891HCID 118090891, compoundYield 42%

Procedure

The procedures of Steps (1), (2) and (3) of Example 12 were repeated step by step, except for using 1-fluoro-2-isocyanato-4-trifluoromethyl benzene instead of benzene in Step (1) of Example 12 to obtain the title compound (60 mg, 42%).

Sources & evidence

ORD record
ord-734e4a6c20b744ef889359dc253293c7
Source dataset
uspto-grants-2016_07
Patent number
US09388165B2

Reaction notes

Loading…