3-Nitrobenzoic acid → HCID 118090882, compound

HRID 1051270Notes

Reaction equation

HRID 1051270 reaction equation
C([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=4)[CH:22]=[CH:21][C:20]=3C)=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)(C)(C)C.[N+](C1C=C(C=CC=1)C(O)=O)([O-])=O>>[NH2:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:20]=[CH:21][CH:22]=[C:23]([C:25](=[O:37])[NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:35])([F:34])[F:36])[CH:28]=4)[CH:24]=3)=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1

Participants

3

Reactant 2

HCID 84973-Nitrobenzoic acidHCID 1180907961-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

Product 1

HCID 118090882HCID 118090882, compoundYield 11%

Procedure

The procedures of Steps (1), (2) and (3) of Example 2 and Step (4) of Example 1 were repeated step by step, except for using 3-nitrobenzoic acid instead of benzoic acid in Step (1) of Example 2 to obtain the title compound (10 mg, 11%).

Sources & evidence

ORD record
ord-651e99e953164a78956edd8f7ad0b959
Source dataset
uspto-grants-2016_07
Patent number
US09388165B2

Reaction notes

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