HRID1051272

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6115

Aniline

C6H7N

结构：Cc1ccc2c(Nc3cccc(C(F)(F)F)c3)nccc2c1N

HCID44478903

未命名化合物

结构：Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12

HCID118090796

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc2c(Nc3cccc(C(F)(F)F)c3)nccc2c1NC(=O)c1cccc2c(N)nccc12

HCID118090798

未命名化合物

收率 2%

PROCEDURE

实验过程

The procedures of Steps (3) and (4) of Example 2 were repeated step by step, except for using 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine obtained in Step (2) above instead of aniline in Step (3) of Example 1 to obtain the title compound (1.0 mg, 2%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f88f749ceefb4e538d8fb2221f7d6f60
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09388165B2
来源说明: uspto-grants-2016_07

反应 SMILES

C([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=O)[NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)(C)(C)C.CC1C=CC2C(NC3C=CC=C(C(F)(F)F)C=3)=[N:45][CH:44]=[CH:43]C=2C=1N.NC1C=CC=CC=1>>[NH2:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[C:20]([CH3:38])=[CH:21][CH:22]=[C:23]4[C:24]=3[CH:43]=[CH:44][N:45]=[C:25]4[NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:35])([F:34])[F:36])[CH:28]=3)=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1