Aniline → HCID 118090794, compound

HRID 1051275Notes

Reaction equation

HRID 1051275 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([C:20]([OH:22])=O)[C:14]=3[CH:13]=[CH:12][N:11]=2)=[N:7][CH:8]=1.NC1C2C=CC=C(C([NH:36][C:37]3[CH:42]=[C:41]([NH:43][C:44]([NH:46][C:47]4[CH:52]=[CH:51][CH:50]=[C:49]([C:53]([F:56])([F:55])[F:54])[CH:48]=4)=[O:45])[CH:40]=[CH:39][C:38]=3[CH3:57])=O)C=2C=CN=1.NC1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([C:20]([NH:36][C:37]4[CH:42]=[C:41]([NH:43][C:44]([NH:46][C:47]5[CH:52]=[CH:51][CH:50]=[C:49]([C:53]([F:54])([F:55])[F:56])[CH:48]=5)=[O:45])[CH:40]=[CH:39][C:38]=4[CH3:57])=[O:22])[C:14]=3[CH:13]=[CH:12][N:11]=2)=[N:7][CH:8]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 118090884HCID 118090884, compoundHCID 118090889HCID 118090889, compound

Product 1

HCID 118090794HCID 118090794, compoundYield 65%

Procedure

The procedures of Example 18 were repeated, except for using 1-((5-methoxypyridin-2-yl)amino)isoquinoline-5-carboxylic acid obtained in Step (3) of Example 19 and 1-(3-amino-4-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea obtained in Example 14 instead of carboxylic acid and aniline in Step (3) of Example 1 to obtain the title compound (48 mg, 65%).

Sources & evidence

ORD record
ord-434790b9c5f94d938f42a7f56261ade1
Source dataset
uspto-grants-2016_07
Patent number
US09388165B2

Reaction notes

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