Aniline → HCID 118090880, compound

HRID 1051276Notes

Reaction equation

HRID 1051276 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([C:20]([OH:22])=O)[C:14]=3[CH:13]=[CH:12][N:11]=2)=[N:7][CH:8]=1.NC1C2C=CC=C(C([NH:36][C:37]3[CH:42]=[C:41]([C:43](=[O:55])[NH:44][C:45]4[CH:50]=[CH:49][CH:48]=[C:47]([C:51]([F:54])([F:53])[F:52])[CH:46]=4)[CH:40]=[CH:39][C:38]=3[CH3:56])=O)C=2C=CN=1.NC1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([C:20]([NH:36][C:37]4[CH:42]=[C:41]([C:43](=[O:55])[NH:44][C:45]5[CH:50]=[CH:49][CH:48]=[C:47]([C:51]([F:52])([F:53])[F:54])[CH:46]=5)[CH:40]=[CH:39][C:38]=4[CH3:56])=[O:22])[C:14]=3[CH:13]=[CH:12][N:11]=2)=[N:7][CH:8]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 118090795HCID 118090795, compoundHCID 118090884HCID 118090884, compound

Product 1

HCID 118090880HCID 118090880, compoundYield 33%

Procedure

The procedures of Example 1 were repeated, except for using 1-((5-methoxypyridin-2-yl)amino)isoquinoline-5-carboxylic acid obtained in Step (3) of Example 19 and 3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide obtained in Example 3 instead of carboxylic acid and aniline in Step (3) of Example 1 to obtain the title compound (24 mg, 33%).

Sources & evidence

ORD record
ord-46766c7278f74392a988356f0cc76d23
Source dataset
uspto-grants-2016_07
Patent number
US09388165B2

Reaction notes

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