HCID 118555039, compound → HCID 118555063, compound

HRID 1051290Notes

Reaction equation

HRID 1051290 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]#[N:10])[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)(=[S:23])C>C(O)(=O)C>[N:1]1([C:6]2[CH:7]=[C:8]([C:9](=[S:23])[NH2:10])[CH:11]=[CH:12][C:13]=2[O:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 118555039HCID 118555039, compoundHCID 178418634HCID 178418634, compound

Product 1

HCID 118555063HCID 118555063, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

A reaction mixture prepared by suspending 65.2 mg of 3-(1H-imidazol-1-yl)-4-phenoxybenzonitrile in a mixture of 0.3 mL of acetic acid and 1.0 mL of thioacetic acid was heated at 50° C. for 14 hours under a nitrogen atmosphere. A crude product of 3-(1H-imidazol-1-yl)-4-phenoxybenzene-1-carbothioamide was obtained by concentrating under reduced pressure.

Workup

  1. customA reaction mixture prepared

Sources & evidence

ORD record
ord-74f7addbe82740bda70c536d7979b4aa
Source dataset
uspto-grants-2016_07
Patent number
US09388174B2

Reaction notes

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