Ethyl 2-(3-nitro-4-phenoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate → Ethyl 2-(3-amino-4-phenoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

A reaction mixture solution prepared by suspending 1.14 g of ethyl 2-(3-nitro-4-phenoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate in 15 mL of ethanol and adding 300 mg of palladium/carbon (10 wt %) was stirred at room temperature for 14 hours under a hydrogen atmosphere. The reaction mixture solution was celite-filtered and the filtrate was concentrated under reduced pressure to obtain 1.05 g of ethyl 2-(3-amino-4-phenoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate.

Provenance & Evidence