Sodium borohydride → HCID 67028257, compound

HRID 1051317Notes

Reaction equation

HRID 1051317 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([CH2:15][OH:16])=[CH:17][CH:18]=3)[N:10]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86631774HCID 86631774, compound

Product 1

HCID 67028257HCID 67028257, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the stirred solution 4-(6-bromo-3-phenylimidazo[1,2-a]pyridin-2-yl)benzaldehyde (0.795 mM) in 15 mL of methanol is added NaBH4 (1.5 eq) at 0° C. and the reaction is allowed to stir at room temperature for 1 hr. The reaction is concentrated and quenched with water. The precipitated solid is filtered and dried to yield the desired product.

Workup

  1. concentrationThe reaction is concentrated
  2. customquenched with water
  3. filtrationThe precipitated solid is filtered
  4. customdried

Sources & evidence

ORD record
ord-7682767a185b41579e27cd2c021cdfee
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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