2-Aminopyrimidine → 4-Imidazo[1,2-a]pyrimidin-2-ylbenzaldehyde

HRID 1051324Notes

Reaction equation

HRID 1051324 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1)=O.[N:13]1[CH:18]=[CH:17][CH:16]=[N:15][C:14]=1[NH2:19]>CC(C)=O>[N:19]1[C:3]([C:5]2[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=2)=[CH:2][N:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=12

Participants

4

Reactant 2

HCID 79782-AminopyrimidineHCID 17755522HCID 17755522, compound

Product 1

HCID 140427944-Imidazo[1,2-a]pyrimidin-2-ylbenzaldehyde

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-(bromoacetyl)benzaldehyde is dissolved in acetone. To it is added pyrimidin-2-amine (1 eq). The reaction mixture is stirred overnight. The precipitated solid is filtered off and dried to obtain the desired compound as a white solid.

Workup

  1. filtrationThe precipitated solid is filtered off
  2. customdried

Sources & evidence

ORD record
ord-164eeb508e734748afee4fb42de9946e
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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