Bromine → HCID 86631783, compound

HRID 1051331Notes

Reaction equation

HRID 1051331 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]2[CH:6]=[C:7]([C:9]3[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[CH:11][CH:10]=3)[N:8]=[C:2]12.[Br:17]Br>C(O)(=O)C>[Br:17][C:6]1[N:3]2[C:2]([S:1][CH:5]=[CH:4]2)=[N:8][C:7]=1[C:9]1[CH:10]=[CH:11][C:12]([CH:13]=[O:14])=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 3982844-Imidazo[2,1-b]thiazol-6-ylbenzaldehyde

Product 1

HCID 86631783HCID 86631783, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

4-Imidazo[2,1-b]thiazol-6-yl-benzaldehyde (3.8 g, 14.9 mM) is dissolved in 30 mL acetic acid. A solution of bromine (1.1 eq) in acetic acid (15 mL) is added to the reaction mixture. The reaction mixture is stirred for 3 h at room temperature. The solid obtained is collected by filtration and re-dissolved in water (100 ml) and the solution neutralized by aqueous ammonia. The solid obtained is collected by filtration and dried.

Workup

  1. customThe solid obtained
  2. filtrationis collected by filtration
  3. dissolutionre-dissolved in water (100 ml)
  4. customThe solid obtained
  5. filtrationis collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-a2012487122f4b878ff32188e9f29e2a
Source dataset
uspto-grants-2016_07
Patent number
US09387204B2

Reaction notes

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