反应详情

To a solution of 48 (2.9 g, 8.4 mmol) in MBTE (40 mL) was added 3N HCl/methanol (6.0 mL, 18 mmol). The mixture was stirred for 2 h at RT. The resulting solid was filtered and washed with MTBE to afford 650 mg (35%) of 50a. 1H NMR (500 MHz, CD3OD) δ 7.46-7.43 (m, 2H), 7.38 (s, 1H), 7.31 (dd, J=10.5, 2.0 Hz, 1H), 7.21 (dd, J=8.5, 1.5 Hz, 1H), 5.13 (s, 1H), 3.85 (s, 3H). LCMS (ESI) m/z: 240.0 [M+H]+.

1. filtrationThe resulting solid was filtered
2. washwashed with MTBE