L-Alaninol → 3-(Tetrahydro-pyran-4-ylamino)-isoquinoline-6-carboxylic acid [(S)-1-(3-fluoro-4-methoxy-phenyl)-2-hydroxy-ethyl]-amide

Participants

Reaction Steps

3-(Tetrahydro-pyran-4-ylamino)-isoquinoline-6-carboxylic acid [(S)-1-(3-fluoro-4-methoxy-phenyl)-2-hydroxy-ethyl]-amide (II-17) was prepared analogously except in step 2, (S)-2-aminopropan-1-ol was replaced with 4-amino-tetrahydropyran and in step 5, 50c was replaced with (S)-2-amino-2-(3-fluoro-4-methoxyphenyl)ethanol hydrochloride (62d). 1H NMR (500 MHz, DMSO-d6) δ 8.91 (s, 1H), 8.76 (d, J=8.5 Hz, 1H), 8.08 (s, 1H), 7.85 (d, J=8.5 Hz, 1H), 7.53 (d, J=9.0 Hz, 1H), 7.27 (d, J=13.0 Hz, 1H), 7.17 (d, J=8.5 Hz, 1H), 7.11 (t, J=8.5 Hz, 1H), 6.73 (s, 1H), 6.55 (d, J=8.0 Hz, 1H), 5.06-5.02 (m, 1H), 4.96 (t, J=5.5 Hz, 1H), 3.91-3.89 (m, 2H), 3.81 (s, 3H), 3.70-3.61 (m, 2H), 3.46-3.42 (m, 3H), 1.94-1.91 (m, 2H), 1.52-1.45 (m, 2H).

Provenance & Evidence