Reaction Steps
N—((R)-(3-Fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-3-yl)methyl)-3-(tetrahydrofuran-3-ylamino)isoquinoline-6-carboxamide (II-27) was prepared analogously except in step 2, (S)-2-aminopropan-1-ol was replaced with 3-amino-tetrahydrofuran and in step 5, 50c was replaced with (R)-(3-fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-3-yl)methanamine hydrochloride (50d). 1H NMR (500 MHz, DMSO-d6) δ 9.26 (d, J=9 Hz, 1H), 8.92 (s, 1H), 8.45 (s, 0.4H), 8.28 (s, 1H), 7.86 (d, J=8.5 Hz, 1H), 7.62 (d, J=2 Hz, 1H), 7.56 (dd, J=8.55, 1.5 Hz, 1H), 7.26 (dd, J=12.5, 1.5 Hz, 1H), 7.18 (d, J=9 Hz, 1H), 7.12 (t, J=9 Hz, 1H), 6.83 (d, J=6 Hz, 1H), 6.70 (s, 1H), 6.32 (d, J=9 Hz, 1H), 6.20 (d, J=2 Hz, 1H), 4.30 (m, 1H), 3.94 (m, 1H), 3.85 (q, J=7.5 Hz, 1H), 3.81 (s, 3H), 3.80 (s, 3H), 3.75 (m, 1H), 3.59 (dd, J=8.5, 3.5 Hz, 1H), 2.22 (m, 1H), 1.87 (m, 1H).
