L-Alaninol → HCID 73335847, compound

Participants

Reaction Steps

N—((S)-(3-Fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-5-yl)methyl)-3-(tetrahydrofuran-3-ylamino)isoquinoline-6-carboxamide (II-31) was prepared analogously except in step 2, (S)-2-aminopropan-1-ol was replaced with 3-amino-tetrahydrofuran and in step 5, (S)-(3-fluoro-4-methoxy-phenyl)-(1-methylpyrazol-4-yl)methanamine hydrochloride was replaced with (S)-(3-fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-5-yl)methanamine hydrochloride (50f). 1H NMR (500 MHz, DMSO-d6) δ 9.46 (s, J=6.5 Hz, 1H), 8.93 (s, 1H), 8.13 (s, 1H), 7.87 (d, J=8.0 Hz, 1H), 7.55 (d, J=7.5 Hz, 1H), 7.34-7.17 (m, 4H), 6.84 (d, J=6.0 Hz, 1H), 6.70 (s, 1H), 6.49 (d, J=8.5 Hz, 1H), 5.95 (d, J=1.5 Hz, 1H), 4.40 (m, 1H), 3.94 (m, 1H), 3.88-3.83 (m, 4H), 3.76-3.74 (m, 4H), 3.59 (m, 1H), 2.20 (m, 1H), 1.89 (m, 1H).

Provenance & Evidence