L-Alaninol → HCID 86712013, compound

Participants

Reaction Steps

3-(Tetrahydro-furan-3-ylamino)-isoquinoline-6-carboxylic acid [(3-fluoro-4-methoxy-phenyl)-(1-methyl-1H-pyrazol-3-yl)-methyl]-amide (II-52) was prepared analogously except in step 2, (S)-2-aminopropan-1-ol was replaced with 3-amino-tetrahydrofuran and in step 5, (S)-(3-fluoro-4-methoxy-phenyl)-(1-methylpyrazol-4-yl)methanamine hydrochloride was replaced with (S)-(3-fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-3-yl)methanamine hydrochloride (50d). 1H NMR (500 MHz, DMSO-d6): δ 9.26 (d, J=9.0 Hz, 1H), 8.93 (s, 1H), 8.28 (s, 0.4H), 8.12 (s, 1H), 7.86 (d, J=8.5 Hz, 1H), 7.63 (s, 1H), 7.62-7.55 (m, 1H), 7.47-7.25 (m, 1H), 7.18 (d, J=9.0 Hz, 1H), 7.14-7.10 (m, 1H), 6.82 (d, J=6.0 Hz, 1H), 6.70 (s, 1H), 6.32 (d, J=9.0 Hz, 1H), 6.20 (s, 1H), 4.31-4.29 (m, 1H), 3.95-3.92 (m, 1H), 3.88-3.72 (m, 8H), 3.61-3.58 (m, 1H), 2.50-2.20 (m, 1H), 1.84-1.76 (m, 1H).

Provenance & Evidence