HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Alaninol → HCID 86712018, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Alaninol | HCID 80307 | — |
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | (S)-(3-fluoro-4-methoxy-phenyl)-(1-methylpyrazol-4-yl)methanamine hydrochloride | HCID 86712001 | — |
| Reactant | HCID 86712019 | HCID 86712019 | — |
| Product | HCID 86712018 | HCID 86712018 | — |
Reaction Steps
3-(Tetrahydro-pyran-4-ylamino)-isoquino line-6-carboxylic acid [(S)-1-(4-difluoromethoxy-phenyl)-2-hydroxy-ethyl]-amide (II-61) was prepared analogously except in step 2, (S)-2-aminopropan-1-ol was replaced with 4-amino-tetrahydropyran and in step 5, (S)-(3-fluoro-4-methoxy-phenyl)-(1-methylpyrazol-4-yl)methanamine hydrochloride was replaced with (S)-2-amino-2-(4-difluoromethoxy-phenyl)ethanol (62h).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388171B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-18939cb810e94cd3a0533dd157411522 |
| Source note | uspto-grants-2016_07 |