Hydrochloric Acid → HCID 86712020, compound

Participants

Reaction Steps

A slurry of 84 (350 mg, 1.181 mmol) and LiOH (62.2 mg, 2.60 mmol) in THF (5.75 mL) and water (0.85 mL) was stirred at RT for 24 h. The THF was removed on a rotary evaporator. The reaction mixture was suspended in water (6 mL) and treated with 10M HCl in water (0.71 mL, 7.1 mmol). A yellow-brown colored precipitate formed and was collected by filtration to afford 3-(1,3-dimethyl-1H-pyrazol-5-ylamino)isoquinoline-6-carboxylic acid (86) which was used in the next step without further purification.

Provenance & Evidence