Lithium Hydroxide → HCID 86712025, compound

Participants

Reaction Steps

A slurry of 96 (132 mg, 0.45 mmol) in THF (2.19 mL) and water (0.324 mL) was treated with solid LiOH (24 mg, 0.99 mmol) and stirred for 3 h. THF was removed in vacuo, and the mixture was suspended in water (6.0 mL) and treated with aqueous HCl (10 M, 0.27 mL). A yellow-brown precipitate was collected by vacuum filtration to afford 3-(2-methylpyridin-4-ylamino)isoquinoline-6-carboxylic acid (98) as a yellow solid, which was used in subsequent steps without further purification.

Provenance & Evidence