Methanesulfonyl chloride → HCID 90133853, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 mL round-bottomed flask, 3,3,3-trifluoro-2-((2-(3-(trifluoromethyl)phenyl)morpholino)-methyl)propan-1-ol (760 mg, 2.13 mmol) was combined with CH2Cl2 (10.0 ml) to give a colorless solution and then cooled to 0° C. DIPEA (412 mg, 557 μl, 3.19 mmol) and methanesulfonyl chloride (244 mg, 166 μl, 2.13 mmol) were added dropwise and the resulting reaction mixture was stirred for 30 min. The reaction was diluted with CH2Cl2 (30 ml), washed with sat. NaHCO3 solution followed by washing with H2O, dried over MgSO4, filtered and concentrated to give 880 mg (95%) of methanesulfonic acid 3,3,3-trifluoro-2-[2-(3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-propyl ester as a colorless oil. MH+=436.

Provenance & Evidence