Tributylphosphine → HCID 118415304, compound

Participants

Reaction Steps

To a 100 mL RB flask containing THF (4381 μl) at 0° C. was added sequentially N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-6-methyl-1H-indazole-5-sulfonamide (4-5, 200 mg, 0.438 mmol), TRI-N-BUTYLPHOSPHINE (216 μl, 0.876 mmol), DTBAD (202 mg, 0.876 mmol) and (S)-tert-butyl 8-(1-hydroxyethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (243 mg, 0.876 mmol). After 50 min at 0° C., concentrated in vacuo. Purified by normal-phase ISCO (40 g column, 0-40% EtOAc:Hex) to give an off-white solid

Provenance & Evidence