HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine, hydrochloride → 5-Bromo-N,N-dimethylpyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Bromo-N,N-dimethylpyrimidin-2-amine | HCID 12735315 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 5-bromo-2-chloropyrimidine (1 g, 5.18 mmol), dimethylamine hydrochloride (1.26 g, 15.6 mmol) and K2CO3 (2.16 g, 15.6 mmol) in EtOH (15 mL) was heated to 120° C. for 16 h. After cooling, the solvent was evaporated off and the residue was used for next step without further purification. LCMS (m/z): 202.1/203.1 [M+H]+/[M+2H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388173B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-de26a70f2a604fa0ba241206bdb44ab4 |
| Source note | uspto-grants-2016_07 |