Dimethylformamide dimethyl acetal → Tert-butyl 4-[(dimethylamino)methylidene]-3-oxopiperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide dimethyl acetal	HCID 78373	—
Reactant	Tert-butyl 3-oxopiperidine-1-carboxylate	HCID 2756825	—
Product	Tert-butyl 4-[(dimethylamino)methylidene]-3-oxopiperidine-1-carboxylate	HCID 66861979	94%

Reaction Conditions

Temperature	100 °C

Reaction Steps

To a stirred mixture of tert-butyl 3-oxopiperidine-1-carboxylate (1 g, 5 mmol) was added DMF-DMA (2 mL). The mixture was stirred at 100° C. for 2 hours. The mixture was concentrated by vacuum and the residue was directly for the next step (1.20 g, yield: 94%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09388173B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-2bd186c8c97e4ac287579dd9dce22430
Source note	uspto-grants-2016_07